Cart
sales@molnova.com
ZK824190
CAS No. 2254001-81-3
ZK824190( —— )
Catalog No. M26523 CAS No. 2254001-81-3
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 560 | In Stock |
|
| 5MG | 541 | In Stock |
|
| 10MG | 775 | In Stock |
|
| 25MG | 1188 | In Stock |
|
| 50MG | 1562 | In Stock |
|
| 100MG | 2111 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameZK824190
-
NoteResearch use only, not for human use.
-
Brief DescriptionZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).
-
DescriptionZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2 mg/kg; p.o.) exhibited a relatively high oral availability(F = 55%; Cmax= 0.64 g/mL and AUC = 2.2 h*g/mL) and a moderate half time of 2.8 h.
-
In Vitro——
-
In VivoZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model Dosage:2?mg/kg (Pharmacokinetic Analysis) Administration:PO Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor5-HT3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2254001-81-3
-
Formula Weight414.409
-
Molecular FormulaC22H20F2N2O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (603.28 mM)
-
SMILESCC[C@@H](Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7.
molnova catalog
related products
-
2-Chlorobenzene-1,3,...
2-Chlorobenzene-1,3,5-triol is a marine derived natural products found in Rhabdonia verticillata.
-
L-BUTHIONINE-(SR)-SU...
L-Buthionine-(SR)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.
-
Cyclic MKEY
MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not been studied.
