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Amodiaquine
CAS No. 86-42-0
Amodiaquine( —— )
Catalog No. M21611 CAS No. 86-42-0
Amodiaquine is a synthetic aminoquinoline used to treat malaria.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
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| 2MG | 61 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 174 | In Stock |
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| 25MG | 303 | In Stock |
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| 50MG | 442 | In Stock |
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| 100MG | 634 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAmodiaquine
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NoteResearch use only, not for human use.
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Brief DescriptionAmodiaquine is a synthetic aminoquinoline used to treat malaria.
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DescriptionAmodiaquine is a synthetic aminoquinoline used to treat malaria.(In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
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In VitroAmodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
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In VivoAmodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration: Intraperitoneal injection; daily; for 3 daysResult:Diminished perihematomal activation of microglia/macrophages and astrocytes.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorNurr1
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Research AreaInfection
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IndicationMalaria
Chemical Information
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CAS Number86-42-0
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Formula Weight355.86
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Molecular FormulaC20H22ClN3O
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Purity>98% (HPLC)
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SolubilityDMSO:71 mg/mL (199.52 mM)
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SMILESCCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Keita Kinoshita Koseiet al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage.[J]. Journal of Neuroimmunology 2019.
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