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GPR183
CAS No. 1241280-25-0
GPR183( 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide )
Catalog No. M28998 CAS No. 1241280-25-0
GPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 141 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 527 | In Stock |
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| 100MG | 714 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGPR183
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NoteResearch use only, not for human use.
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Brief DescriptionGPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD).
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DescriptionGPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD).
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In VitroSAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM. Cell Viability Assay Cell Line:The human leukemia (HL)-60 cells Concentration:5×of the antagonist Incubation Time:15 min Result:Had GPR183-specific (IC50: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.
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In VivoSAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice. Animal Model:Male and female ICR mice Dosage:2.9 μM Administration:intrathecal (i.th.) injections; 2.9 μM; once Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.
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Synonyms3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1241280-25-0
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Formula Weight364.368
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Molecular FormulaC19H19F3N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (274.45 mM)
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SMILESFc1cc(NC(=O)CCc2ccc(F)c(F)c2)cc(c1)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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