VU0238429( SCR-1481B1 )

Catalog No. M21562 CAS No. 1160247-92-6

VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	50	In Stock
2MG	29	In Stock
5MG	46	In Stock
10MG	74	In Stock
25MG	140	In Stock
50MG	222	In Stock
100MG	352	In Stock
200MG	Get Quote	In Stock
500MG	821	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

VU0238429
Note

Research use only, not for human use.
Brief Description

VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
Description

VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
In Vitro

VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity.
In Vivo

——
Synonyms

SCR-1481B1
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

M5 mAChR
Research Area

——
Indication

——

Chemical Information

CAS Number

1160247-92-6
Formula Weight

351.28
Molecular Formula

C17H12F3NO4
Purity

>98% (HPLC)
Solubility

DMSO:150 mg/mL (427.01 mM)
SMILES

COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
Chemical Name

1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-23-dihydro-1H-indole-23-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Bridges TM et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

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