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VU0238429

CAS No. 1160247-92-6

VU0238429( SCR-1481B1 )

Catalog No. M21562 CAS No. 1160247-92-6

VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 50 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 74 In Stock
25MG 140 In Stock
50MG 222 In Stock
100MG 352 In Stock
200MG Get Quote In Stock
500MG 821 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VU0238429
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
  • Description
    VU0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).
  • In Vitro
    VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity.
  • In Vivo
    ——
  • Synonyms
    SCR-1481B1
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    M5 mAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1160247-92-6
  • Formula Weight
    351.28
  • Molecular Formula
    C17H12F3NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (427.01 mM)
  • SMILES
    COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
  • Chemical Name
    1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-23-dihydro-1H-indole-23-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bridges TM et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
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