Tilianin( —— )

Catalog No. M21503 CAS No. 4291-60-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tilianin
Note

Research use only, not for human use.
Brief Description

Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L.
Description

Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L.
In Vitro

Tilianin (10 μM, 20 μM) reduced secretion of LPS (1 μg/mL)-induced proinflammatory cytokine in RAW264.7 macrophage cell.
In Vivo

Tilianin (10 mg/kg; i.p.) is a potential agent for ameliorating LPS-induced acute lung injury (ALI).Tilianin shows Tmax=10.8 min,Cmax=176.9 nmol/L, AUC0-∞= 17.4 min*μmol/L in mice. Animal Model:C57BL/6 mouse Dosage:10 mg/kg Administration:Intraperitoneal injection Result:Attenuated infiltration of macrophages and histopathological changes and improved inflammation.Animal Model:Male FVB mice (6-10 weeks) Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Oral gavage Result:Tmax(10.8 min), Cmax(176.9 nmol/L), AUC0-∞(17.4 min*μmol/L).
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

4291-60-5
Formula Weight

446.4
Molecular Formula

C22H22O10
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (112.01 mM)
SMILES

COc(cc1)ccc1C(Oc1c2c(O)cc(O[C@@H]([C@@H]([C@H]3O)O)O[C@H](CO)[C@H]3O)c1)=CC2=O
Chemical Name

——

1.Sergienko TO et al. Moldavoside--new flavonoid glycoside of Dragocephalum moldavicum L. Farm Zh. 1968;23(2):75-8.

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