Securinine

Research use only, not for human use.

(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.

(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.(In Vitro):(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.(In Vivo):In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.

(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily(TNFRSF) genes in the cells stimulated with (-)-Securinine.

In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.

(-)-Securinine

Others

Other Targets

GABAA

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5610-40-2

217.26

C13H15NO2

>98% (HPLC)

DMSO:2 mg/mL (9.21 mM)

O=C1O[C@](C2)([C@@H](CCCC3)N3[C@@H]2C=C2)C2=C1

(6S11aR11bS)-9101111a-tetrahydro-8H-611b-methanofuro[23-c]pyrido[12-a]azepin-2(6H)-one

(-20℃)

With Ice Pack

≥ 2 years