4'-Hydroxychalcone

Research use only, not for human use.

4'-Hydroxychalcone is a chalcone metabolite with hepatoprotective activity.

4'-Hydroxychalcone is a chalcone metabolite with hepatoprotective activity.

4'-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner.4'-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity.4'-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-Hydroxychalcone-inhibited expression of NF-kB target genes.4'-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability. Cell Viability Assay Cell Line:K562 cells, Jurkat cells, U937 cells, PBMCs Concentration:5 μM, 10 μM, 20 μM, 24 μM, 28 μM, 32 μM, 40 μM, 60 μM Incubation Time:24 hours Result:Affected cancer cell viability but has no significant effect on non-transformed cell viability.Western Blot Analysis Cell Line:Jurkat cells Concentration:60 μM (followed by TNFα 20 ng/mL )Incubation Time:2 hours Result:Inhibited TNFα -dependent degradation of IkBαand prevents p50/p65 nuclear translocation.

4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice. Animal Model:Male albino mice(5-30 g)Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg Administration:Oral administration, 12h intervals, 4 doses Result:Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).

2-Benzal-4-Hydroxyacetophenone

Others

Other Targets

Others

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2657-25-2

224.25

C15H12O2

>98% (HPLC)

DMSO:25 mg/mL (1114.83 mM)

Oc1ccc(cc1)C(=O)\C=C\c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years