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TCN-201

CAS No. 852918-02-6

TCN-201( —— )

Catalog No. M21167 CAS No. 852918-02-6

TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TCN-201
  • Note
    Research use only, not for human use.
  • Brief Description
    TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
  • Description
    TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
  • In Vitro
    TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC50s of 6.8 and <4.3, respectively.TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.
  • In Vivo
    TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    NMDA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    852918-02-6
  • Formula Weight
    461.89
  • Molecular Formula
    C21H17ClFN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:20mg/ml(43.3mM)
  • SMILES
    O=C(NNC(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cc1)c1ccccc1
  • Chemical Name
    4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-benzoic acid 2-benzoylhydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hansen K B Ogden K K Traynelis S . Subunit-selective allosteric inhibition of glycine binding to NMDA receptors[J]. journal of neuroscience the official journal of the society for neuroscience 2012 32(18):6197.
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