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Cardiogenol C hydrochloride(b)
CAS No. 1049741-55-0
Cardiogenol C hydrochloride(b)( Cardiogenol C | Cardiogenol C HCl )
Catalog No. M21118 CAS No. 1049741-55-0
Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 96 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 267 | In Stock |
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| 200MG | 383 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCardiogenol C hydrochloride(b)
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NoteResearch use only, not for human use.
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Brief DescriptionCardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
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DescriptionCardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
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In VitroCardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,?nppa) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells. RT-PCR Cell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM Incubation Time:7 days Result:Increased ANF and NKX2.5 mRNA level as a dose-dependent manner. Western Blot Analysis Cell Line:C2C12 cells Concentration:0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM Incubation Time:7 days Result:Increased cardiac Nav1.5 sodium channel protein levels.Cell Proliferation Assay Cell Line:C2C12 cells Concentration:0.01 μM; 0.1 μM; 1 μM Incubation Time:7 days Result:Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
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In Vivo——
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SynonymsCardiogenol C | Cardiogenol C HCl
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt
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Research Area——
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Indication——
Chemical Information
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CAS Number1049741-55-0
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Formula Weight296.75
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Molecular FormulaC13H17ClN4O2
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Purity>98% (HPLC)
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SolubilityDMSO:59 mg/mL (198.82 mM)H2O:2 mg/mL (6.74 mM; Need ultrasonic)
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SMILESCOc1ccc(Nc2nccc(NCCO)n2)cc1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yau Winifred WY Tang Mei-Kuen Chen Elveet al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells[J]. Proteome Science 9(1):3.
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