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Salvigenin
CAS No. 19103-54-9
Salvigenin( —— )
Catalog No. M21116 CAS No. 19103-54-9
Salvigenin is a potent hMAO-A inhibitor has neuroprotective antitumor and immunomodulatory effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 143 | In Stock |
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| 10MG | 237 | In Stock |
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| 25MG | 402 | In Stock |
|
| 50MG | 581 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSalvigenin
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NoteResearch use only, not for human use.
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Brief DescriptionSalvigenin is a potent hMAO-A inhibitor has neuroprotective antitumor and immunomodulatory effects.
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DescriptionSalvigenin is a potent hMAO-A inhibitor has neuroprotective antitumor and immunomodulatory effects.
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In VitroSalvigenin (0-100 μM, 3 h) protects SH-SY5Y cells against H2O2-induced cell death.Salvigenin (0-100 μM, 2 h) significantly reduces ROS generation, increases the glutathione level, declines the extent of cell apoptosis and increases autophagy in H2O2-exposed SH-SY5Y cells. Cell Viability Assay Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:3 h Result:Protected SH-SY5Y cells (best in 25 and 50μM) against H2O2-induced cell death.Apoptosis Analysis Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:2 h Result:Significantly declined the extent of cell apoptosis induced by H2O2.Western Blot Analysis Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:2 h Result:Reduced cleaved caspase-3 and Bax/Bcl-2 ratio. Reduced caspase-12 and calpain levels. Reduced the level of Atg7, Atg12, and LC3-II/ LC3-I.
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In VivoSalvigenin (0-9.68 μg/mouse/day; i.p.; 4 or 12 days) shows antitumor and immunomodulatory effects on tumor bearing mice. Animal Model:MCF-7 cell bearing inbred female Balb/c mice, aged from six to eight weeks Dosage:3.65, 5.85 and 9.68 μg/mouse/day for four days or 12 days Administration:Intraperitoneal injectionResult:Showed a significant increase in DTH response in a dose-dependent manner. Significantly decreased the rate of tumor growth, increased lymphocyte proliferation index, increased the level of IFN-γ and decreased IL-4 production. Exhibited a significant decrease of the splenic CD4+CD25+Foxp3+ T lymphocytes.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMAO
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RecptorhMAO-A
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Research Area——
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Indication——
Chemical Information
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CAS Number19103-54-9
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Formula Weight328.32
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Molecular FormulaC18H16O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (60.92 mM)
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SMILESCOc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)cc3o2)cc1
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Chemical Name5-hydroxy-67-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sarvestani N N Sepehri H Delphi L et al. Eupatorin and Salvigenin Potentiate Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in HT-29 and SW948 Human Colon Cancer Cells[J]. Asian Pacific Journal of Cancer Prevention Apjcp 2018 19(1):131-139.
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