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SM 324405
CAS No. 677773-91-0
SM 324405( —— )
Catalog No. M21108 CAS No. 677773-91-0
SM 324405 is an agonist of TLR7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 141 | In Stock |
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| 50MG | 221 | In Stock |
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| 100MG | 317 | In Stock |
|
| 200MG | 442 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSM 324405
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NoteResearch use only, not for human use.
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Brief DescriptionSM 324405 is an agonist of TLR7.
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DescriptionSM 324405 is an agonist of TLR7.
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In VitroSM-324405 is a novel candidate for immunotherapy of allergic diseases.
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In VivoSM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR7
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Research Area——
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Indication——
Chemical Information
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CAS Number677773-91-0
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Formula Weight385.42
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Molecular FormulaC19H23N5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (129.73 mM)
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SMILESCCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1
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Chemical NameMethyl 3-[(6-amino-2-butoxy-78-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kurimoto A Hashimoto K Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72.
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