Cart
sales@molnova.com
SM 324405
CAS No. 677773-91-0
SM 324405( —— )
Catalog No. M21108 CAS No. 677773-91-0
SM 324405 is an agonist of TLR7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
|
| 2MG | 29 | In Stock |
|
| 5MG | 48 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 141 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | 317 | In Stock |
|
| 200MG | 442 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSM 324405
-
NoteResearch use only, not for human use.
-
Brief DescriptionSM 324405 is an agonist of TLR7.
-
DescriptionSM 324405 is an agonist of TLR7.
-
In VitroSM-324405 is a novel candidate for immunotherapy of allergic diseases.
-
In VivoSM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetTLR
-
RecptorTLR7
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number677773-91-0
-
Formula Weight385.42
-
Molecular FormulaC19H23N5O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (129.73 mM)
-
SMILESCCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1
-
Chemical NameMethyl 3-[(6-amino-2-butoxy-78-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Kurimoto A Hashimoto K Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72.
molnova catalog
related products
-
Imiquimod
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
-
Procyanidin B1
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells.
-
Chloranil
Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflammation in mice.
