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SM 324405

CAS No. 677773-91-0

SM 324405( —— )

Catalog No. M21108 CAS No. 677773-91-0

SM 324405 is an agonist of TLR7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 52 In Stock
2MG 29 In Stock
5MG 48 In Stock
10MG 77 In Stock
25MG 141 In Stock
50MG 221 In Stock
100MG 317 In Stock
200MG 442 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    SM 324405
  • Note
    Research use only, not for human use.
  • Brief Description
    SM 324405 is an agonist of TLR7.
  • Description
    SM 324405 is an agonist of TLR7.
  • In Vitro
    SM-324405 is a novel candidate for immunotherapy of allergic diseases.
  • In Vivo
    SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    677773-91-0
  • Formula Weight
    385.42
  • Molecular Formula
    C19H23N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.73 mM)
  • SMILES
    CCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1
  • Chemical Name
    Methyl 3-[(6-amino-2-butoxy-78-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kurimoto A Hashimoto K Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72.
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