AVex-73

Research use only, not for human use.

AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.

AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.

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Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration.Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice. Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response.Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice. Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice Dosage:10 mg/kg, 30 mg/kg Administration:Oral administration, daily, for 6.5 weeks Result:Reverse the deficits observed in the HET animals.

Blarcamesine | AE-37

Endocrinology/Hormones

AChR

muscarinic receptor

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195615-83-9

281.39

C19H23NO

>98% (HPLC)

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CN(C)CC1CCOC1(C1=CC=CC=C1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years