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AVex-73
CAS No. 195615-83-9
AVex-73( Blarcamesine | AE-37 )
Catalog No. M21059 CAS No. 195615-83-9
AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 276 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAVex-73
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NoteResearch use only, not for human use.
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Brief DescriptionAVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
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DescriptionAVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
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In Vitro——
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In VivoBlarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration.Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice. Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response.Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice. Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice Dosage:10 mg/kg, 30 mg/kg Administration:Oral administration, daily, for 6.5 weeks Result:Reverse the deficits observed in the HET animals.
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SynonymsBlarcamesine | AE-37
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptormuscarinic receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number195615-83-9
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Formula Weight281.39
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Molecular FormulaC19H23NO
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Purity>98% (HPLC)
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Solubility——
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SMILESCN(C)CC1CCOC1(C1=CC=CC=C1)C1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Matsueda Gao S Efferson H et al. N-terminally LRMK-linked HER-2 peptides AE-37[J]. 2009.
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