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DS-1001b
CAS No. 1898207-64-1
DS-1001b( —— )
Catalog No. M21053 CAS No. 1898207-64-1
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 276 | In Stock |
|
| 100MG | 431 | In Stock |
|
| 200MG | 621 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDS-1001b
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NoteResearch use only, not for human use.
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Brief DescriptionDS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).
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DescriptionDS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).
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In VitroCell Proliferation Assay Cell Line:JJ012, L835 Concentration:0.1, 1, 10 μM Incubation Time:14 days Result:Inhibited cell proliferation in a dose-dependent manner. GI50 values for JJ012, L835 are 81 and 77 nM.RT-PCR Cell Line:L835 Concentration:10 μM Incubation Time:6 weeks Result:Upregulated the expression of SOX9, RUNX2, COL2A1, COL10A1 and ACAN.Cell Cycle Analysis Cell Line:JJ012 Concentration:1 μM Incubation Time:7 days Result:Induced G1 phase arrest. Increased the percentage of cells in the G0/G1 phase by 5.4% and decreased that of cells in the S phase by 4.4%.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorIDH1
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Research AreaCancer
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IndicationGlioma
Chemical Information
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CAS Number1898207-64-1
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Formula Weight608.92
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Molecular FormulaC29H29Cl3FN3O4
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Purity>98% (HPLC)
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SolubilityDMSO:14 mg/mL (22.99 mM)
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SMILESCC(C)(C)N.Cc1cn(C(=O)c2c(-c3c(Cl)cc(Cl)cc3Cl)noc2C(C)(C)F)c2cccc(/C=C/C(=O)O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yoshiki A Yohei M Toshihiko W et al. ACT-14 A FIRST-IN-HUMAN STUDY OF MUTANT IDH1 INHIBITOR DS-1001B IN PATIENTS WITH RECURRENT GLIOMAS[J]. Neuro Oncology Advances(Supplement_2):Supplement_2.
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