Cyclo(his-pro)

Research use only, not for human use.

Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.

Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.

cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors. cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release. Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Western Blot AnalysisCell Line:PC12 cells Concentration:50 μM Incubation Time:1, 2, 4, 8, 24, 48 hours Result:Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation.

Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect. Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress. Animal Model:Sixty two/three month-old male C57BL/6 mice (25-30 g)Dosage:1.8 mg/ear Administration:Topical application on the right ear; 30 min prior to TPA Result:Reduced TPA-induced ear oedema.

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Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite |NF-κB

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53109-32-3

234.25

C11H14N4O2

>98% (HPLC)

H2O:30 mg/mL (128.07 mM)

O=C1NC(Cc2cnc[nH]2)C(=O)N2CCCC12

(3S8aS)-3-((1H-imidazol-4-yl)methyl)hexahydropyrrolo[12-a]pyrazine-14-dione

(-20℃)

With Ice Pack

≥ 2 years