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Cyclo(his-pro)
CAS No. 53109-32-3
Cyclo(his-pro)( —— )
Catalog No. M21020 CAS No. 53109-32-3
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 397 | In Stock |
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| 100MG | 584 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCyclo(his-pro)
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NoteResearch use only, not for human use.
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Brief DescriptionCyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.
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DescriptionCyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.
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In Vitrocyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors. cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release. Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Western Blot AnalysisCell Line:PC12 cells Concentration:50 μM Incubation Time:1, 2, 4, 8, 24, 48 hours Result:Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation.
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In VivoCyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect. Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress. Animal Model:Sixty two/three month-old male C57BL/6 mice (25-30 g)Dosage:1.8 mg/ear Administration:Topical application on the right ear; 30 min prior to TPA Result:Reduced TPA-induced ear oedema.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite |NF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number53109-32-3
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Formula Weight234.25
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Molecular FormulaC11H14N4O2
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Purity>98% (HPLC)
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SolubilityH2O:30 mg/mL (128.07 mM)
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SMILESO=C1NC(Cc2cnc[nH]2)C(=O)N2CCCC12
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Chemical Name(3S8aS)-3-((1H-imidazol-4-yl)methyl)hexahydropyrrolo[12-a]pyrazine-14-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Tuftsin diacetate
Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages.
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L-Homocystine
Homocystine is the double-bonded form of homocysteine but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an elevation of homocysteine in schizophrenia.
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3-Hydroxybutyric aci...
3-Hydroxybutyric acid (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone) levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans 3-hydroxybutyrate is synthesized in the liver from acetyl-CoA and can be used as an energy source by the brain when blood glucose is low.
