Pyributicarb

Research use only, not for human use.

Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).

Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus.

TSH-888

Metabolic Enzyme/Protease

P450

CYP3A4

——

——

88678-67-5

330.44

C18H22N2O2S

>98% (HPLC)

DMSO:100 mg/mL (302.63 mM)

COc1cccc(N(C)C(=S)Oc2cccc(C(C)(C)C)c2)n1

——

(-20℃)

With Ice Pack

≥ 2 years