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Datelliptium chloride hydrochloride
CAS No. 157000-76-5
Datelliptium chloride hydrochloride( —— )
Catalog No. M20926 CAS No. 157000-76-5
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 866 | In Stock |
|
| 10MG | 1121 | In Stock |
|
| 25MG | 1691 | In Stock |
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| 50MG | 2213 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDatelliptium chloride hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDatelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
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DescriptionDatelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
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In VitroDatelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
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In VivoDatelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210. Animal Model:Mice, colon adenocarcinoma early staged disease model Dosage:170 mg/kg Administration: Intravenous injection, for 12 days Result:Showed potent activity against colon adenocarcinoma.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number157000-76-5
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Formula Weight434.4
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Molecular FormulaC23H29Cl2N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.Cl.[Cl-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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JH-RE-06
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
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NSAH?
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.A unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays.?NSAH binds to hRRM1 with an apparent dissociation constant of 37 μM, and steady-state kinetics reveal a competitive mode of inhibition.?
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ZIM
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation.
