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Datelliptium chloride hydrochloride

CAS No. 157000-76-5

Datelliptium chloride hydrochloride( —— )

Catalog No. M20926 CAS No. 157000-76-5

Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Datelliptium chloride hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
  • Description
    Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
  • In Vitro
    Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
  • In Vivo
    Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210. Animal Model:Mice, colon adenocarcinoma early staged disease model Dosage:170 mg/kg Administration: Intravenous injection, for 12 days Result:Showed potent activity against colon adenocarcinoma.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    157000-76-5
  • Formula Weight
    434.4
  • Molecular Formula
    C23H29Cl2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.Cl.[Cl-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mucci-Lorusso P Polin L Biernat L A et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice[J]. Investigational New Drugs 1990 8(3):253-261.
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