Thyrotropin-Releasing Hormone (TRH) Free Acid

Research use only, not for human use.

Thyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.

Thyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.

TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.

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TRH-OH

Others

Other Targets

Others

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24769-58-2

363.37

C16H21N5O5

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (275.20 mM)

O=C1CCC(C(=O)NC(Cc2c[nH]cn2)C(=O)N2CCCC2C(=O)O)N1

((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-proline

(-20℃)

With Ice Pack

≥ 2 years