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Home - Products - Metabolic Enzyme/Protease - P450 - Furafylline

Furafylline

CAS No. 80288-49-9

Furafylline( —— )

Catalog No. M20761 CAS No. 80288-49-9

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 268 In Stock
5MG 235 In Stock
10MG 349 In Stock
25MG 594 In Stock
50MG 814 In Stock
100MG 1135 In Stock
200MG 1535 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Furafylline
  • Note
    Research use only, not for human use.
  • Brief Description
    Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
  • Description
    Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
  • In Vitro
    ——
  • In Vivo
    Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    CYP450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    80288-49-9
  • Formula Weight
    260.25
  • Molecular Formula
    C12H12N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL (48.03 mM)
  • SMILES
    Cc1nc2n(Cc3ccco3)c(=O)n(C)c(=O)c2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sesardic D Boobis A R Murray B P et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.[J]. British Journal of Clinical Pharmacology 1990 29(6):651-663.
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