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S29434
CAS No. 874484-20-5
S29434( —— )
Catalog No. M20697 CAS No. 874484-20-5
S29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
|
| 5MG | 116 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameS29434
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NoteResearch use only, not for human use.
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Brief DescriptionS29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
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DescriptionS29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
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In VitroCell Autophagy Assay Cell Line:HepG2 cell line Concentration:5 and 10 μM Incubation Time:24 hours Result:Mitochondrial ROS-independently and QR2-dependently triggered autophagy, and dose-dependently induced LC3-II which is a marker of autophagy vesicles.
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In VivoAnimal Model:CH3 wild-type mice Dosage:1 and 15 mg/kg Administration:Intraperitoneal injection; 1 and 15 mg/kg once Result:Positively affected memory by inhibiting QR2.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorQuinone reductase 2(QR2)
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Research Area——
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Indication——
Chemical Information
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CAS Number874484-20-5
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Formula Weight374.39
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Molecular FormulaC21H18N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:12.5 mg/mL?(33.39 mM)
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SMILESCOc1ccc2n3Cc4cccnc4-c3c(CCNC(=O)c3ccco3)c2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Boutin JA Bouillaud F Janda Eet al.S29434 a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization[J].Mol Pharmacol. 2019 Mar;95(3):269-285.
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