Tildipirosin

Research use only, not for human use.

Tildipirosin is a 16-membered macrolide used as an antibiotic in veterinary medicine. Like other macrolides it inhibits protein synthesis in bacteria and blocks the production of biofilms.

Tildipirosin is a 16-membered macrolide used as an antibiotic in veterinary medicine. Like other macrolides it inhibits protein synthesis in bacteria and blocks the production of biofilms.

Tildipirosin exhibits the inhibitory effect on C. coli species, and 23 of 31 (74%) isolates have MICs of 8 or 16 μg/mL while 8 of 31 (26%) have MIC >256 μg/mL. MICs against C. jejuni are 8-64 μg/mL. Tildipirosin against S. enterica and E. coli are 2-8 μg/mL. Tildipirosin inhibits the treponeme isolates form from CODD lesions from 19 sheep, with MIC90 of 0.0469 mg/L. The P. multocida B130 clones show the MIC of 0.25 mg/L for tildipirosin. The 10 P. multocida isolates that carry only erm(42) exhibit MIC of 16-32 mg/L for tildipirosin. The single M. haemolytica that harbours only erm(42) shows MIC of 32 mg/L for tildipirosin.

The mean percentage of lung consolidation for tildipirosin (4 mg/kg, s.c.)-treated calves is significantly lower than those for tulathromycin-treated and control calves. Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevents subsequent culture of the pathogen from bronchial secretions and is more effective in minimizing clinical disease and lung lesions than is metaphylactic administration of tulathromycin.

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GPCR/G Protein

Antibacterial

Bacterial

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328898-40-4

734.02

C41H71N3O8

>98% (HPLC)

DMSO:100 mg/mL (136.24 mM)

CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H]([C@H]2O)N(C)C)[C@@H](CCN2CCCCC2)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@@H]1CN1CCCCC1

(5S6S7R9R11E13E15R16R)-6-(((2R3R4S5S6R)-4-(dimethylamino)-35-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-5913-trimethyl-7-(2-(piperidin-1-yl)ethyl)-15-(piperidin-1-ylmethyl)oxacyclohexadeca-1113-diene-210-dione

(-20℃)

With Ice Pack

≥ 2 years