44'-DIMETHOXYBENZIL( p-Anisil )

Catalog No. M20521 CAS No. 1226-42-2

44'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	28	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	27	In Stock

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Biological Information

Product Name

44'-DIMETHOXYBENZIL
Note

Research use only, not for human use.
Brief Description

44'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).
Description

44'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).
In Vitro

By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4'-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed.
In Vivo

——
Synonyms

p-Anisil
Pathway

Others
Target

Other Targets
Recptor

hiCE
Research Area

——
Indication

——

Chemical Information

CAS Number

1226-42-2
Formula Weight

270.28
Molecular Formula

C16H14O4
Purity

>98% (HPLC)
Solubility

DMSO:50 mg/mL (184.99 mM)
SMILES

COc1ccc(cc1)C(=O)C(=O)c1ccc(OC)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Guodong Z Hu G E Qiong G U et al. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands[J]. Science China(Chemistry) 2013(10):80-90.

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