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Paederosidic acid

CAS No. 18842-98-3

Paederosidic acid( —— )

Catalog No. M20407 CAS No. 18842-98-3

Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Paederosidic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
  • Description
    Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
  • In Vitro
    Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of40.68, 42.58, and 36.48 μg/ml, respectively.Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation ofBcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells..
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    18842-98-3
  • Formula Weight
    464.4
  • Molecular Formula
    C18H24O12S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (215.31 mM)
  • SMILES
    [H][C@]12[C@@H](O)C=C(COC(=O)SC)[C@@]1([H])[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yu P Shi L Song M et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis[J]. Chemico-Biological Interactions 2017 269:33-40.
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