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GSK8612
CAS No. 2361659-62-1
GSK8612( —— )
Catalog No. M20260 CAS No. 2361659-62-1
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1 pIC50: 6.8).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 80 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 369 | In Stock |
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| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK8612
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NoteResearch use only, not for human use.
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Brief DescriptionGSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1 pIC50: 6.8).
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DescriptionGSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1 pIC50: 6.8).
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In VitroGSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorTBK1
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Research Area——
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Indication——
Chemical Information
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CAS Number2361659-62-1
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Formula Weight520.33
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Molecular FormulaC17H17BrF3N7O2S
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (192.19 mM);Water: Insoluble
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SMILESCc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Thomson DW et al. Discovery of GSK8612 a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.
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