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SRI 31215
CAS No. 1832686-44-8
SRI 31215( —— )
Catalog No. M20215 CAS No. 1832686-44-8
SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
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| 5MG | 84 | In Stock |
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| 10MG | 130 | In Stock |
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| 25MG | 261 | In Stock |
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| 50MG | 383 | In Stock |
|
| 100MG | 545 | In Stock |
|
| 200MG | 737 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSRI 31215
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NoteResearch use only, not for human use.
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Brief DescriptionSRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM.
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DescriptionSRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM
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In VitroWestern Blot Analysis Cell Line:DU145 cells Concentration:10 μM Incubation Time:30 min Result:Prevented fibroblast-induced MET activation and signaling in tumor cells, but did not prevent MET activation induced by active HGF.Cell Migration Assay Cell Line:DU145 cells Concentration:10 μM Incubation Time:24 h Result:Did not interfere with HGF-induced migration, but inhibited fibroblast-induced migration of DU145 cells.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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Targetc-Met/HGFR
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RecptorHGFA|matriptase|hepsin
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Research Area——
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Indication——
Chemical Information
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CAS Number1832686-44-8
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Formula Weight533.6
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Molecular FormulaC27H34F3N5O3
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESOC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(C1)c1cccc(c1)C(N)=N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Owusu BY et al. Inhibition of pro-HGF activation by SRI31215 a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.
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