D3-βArr

CAS No. 662164-09-2

D3-βArr( NCGC00379308 )

Catalog No. M20139 CAS No. 662164-09-2

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 33 In Stock
5MG 29 In Stock
10MG 49 In Stock
25MG 107 In Stock
50MG 183 In Stock
100MG 272 In Stock
200MG 405 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    D3-βArr
  • Note
    Research use only, not for human use.
  • Brief Description
    D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
  • Description
    D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NCGC00379308
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    thyrotropin receptor (TSHR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    662164-09-2
  • Formula Weight
    333.43
  • Molecular Formula
    C20H23N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (299.91 mM)
  • SMILES
    CC(Nc1nc(nc2ccccc12)N1CCNCC1)c1ccccc1
  • Chemical Name
    N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Neumann S et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.
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