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Eprotirome
CAS No. 355129-15-6
Eprotirome( KB2115 )
Catalog No. M20098 CAS No. 355129-15-6
Eprotirome a synthetic thyroid hormone mimetic is a thyroid hormone receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 148 | In Stock |
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| 50MG | 230 | In Stock |
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| 100MG | 368 | In Stock |
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| 200MG | 538 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEprotirome
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NoteResearch use only, not for human use.
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Brief DescriptionEprotirome a synthetic thyroid hormone mimetic is a thyroid hormone receptor agonist.
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DescriptionEprotirome a synthetic thyroid hormone mimetic is a thyroid hormone receptor agonist.(In Vivo):Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.
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In Vitro——
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In VivoEprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.
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SynonymsKB2115
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorTHR
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Research AreaMetabolic Disease
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IndicationDyslipidaemias; Hypercholesterolaemia; Obesity
Chemical Information
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CAS Number355129-15-6
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Formula Weight487.14
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Molecular FormulaC18H17Br2NO5
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Purity>98% (HPLC)
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SolubilityDMSO: 90 mg/mL (184.75 mM);Ethanol: 30 mg/mL
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SMILESCC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(O)=O)cc2Br)ccc1O
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Chemical Name3-((35-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Berkenstam A et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):663-7.
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