Propylthiouracil( NSC 6498 | NSC 70461 | 6-n-Propylthiouracil | PTU )

Catalog No. M14789 CAS No. 51-52-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Propylthiouracil
Note

Research use only, not for human use.
Brief Description

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor.
Description

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor. A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism.
In Vitro

Cell Viability Assay Cell Line:U-937 cells Concentration:5.5 μg/mL, 11 μg/mL, 110 μg/mL, 220 μg/mL, 330 μg/mL Incubation Time:24 hours Result:Induced cytotoxicity in a dose-dependent manner.
In Vivo

Animal Model:Adult C57BL/6J and wild-derived WSB/EiJ male mice (8-weeks old)Dosage:1.5 g/kg diet Administration:Iodine-deficient diet; for 7 weeks Result:Induced hypothyroidism in adult C57BL/6J and wild-derived WSB/EiJ male mice.
Synonyms

NSC 6498 | NSC 70461 | 6-n-Propylthiouracil | PTU
Pathway

Endocrinology/Hormones
Target

THR
Recptor

Thyroid peripheral conversion
Research Area

Endocrinology
Indication

——

CAS Number

51-52-5
Formula Weight

170.24
Molecular Formula

C7H10N2OS
Purity

>98% (HPLC)
Solubility

Ethanol: 19 mg/mL (111.61 mM); DMSO: 34 mg/mL (199.72 mM)
SMILES

CCCC1=CC(=O)NC(=S)N1
Chemical Name

6-(2,2,3,3,3-pentadeuteriopropyl)-2-sulfanylidene-1H-pyrimidin-4-one

1.Sugawara M, et al. Thyroid. 1999 May;9(5):513-8.

Calculator

molnova catalog