Hypotaurine

Research use only, not for human use.

Hypotaurine an intermediate in taurine biosynthesis from cysteine in astrocytes is an endogenous inhibitory amino acid of the glycine receptor.

Hypotaurine an intermediate in taurine biosynthesis from cysteine in astrocytes is an endogenous inhibitory amino acid of the glycine receptor.

Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.

Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.

2-Aminoethanesulfinic acid | 2-Aminoethylsulfinic acid

Membrane Transporter/Ion Channel

Chloride Channel

Glycine receptor

——

——

300-84-5

109.15

C2H7NO2S

>98% (HPLC)

H2O:150 mg/mL (1374.26 mM)

NCCS(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years