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Hypotaurine
CAS No. 300-84-5
Hypotaurine( 2-Aminoethanesulfinic acid | 2-Aminoethylsulfinic acid )
Catalog No. M20061 CAS No. 300-84-5
Hypotaurine an intermediate in taurine biosynthesis from cysteine in astrocytes is an endogenous inhibitory amino acid of the glycine receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 29 | In Stock |
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| 25MG | 44 | In Stock |
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| 50MG | 60 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHypotaurine
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NoteResearch use only, not for human use.
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Brief DescriptionHypotaurine an intermediate in taurine biosynthesis from cysteine in astrocytes is an endogenous inhibitory amino acid of the glycine receptor.
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DescriptionHypotaurine an intermediate in taurine biosynthesis from cysteine in astrocytes is an endogenous inhibitory amino acid of the glycine receptor.
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In VitroHypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.
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In VivoHypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.
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Synonyms2-Aminoethanesulfinic acid | 2-Aminoethylsulfinic acid
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PathwayMembrane Transporter/Ion Channel
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TargetChloride Channel
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RecptorGlycine receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number300-84-5
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Formula Weight109.15
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Molecular FormulaC2H7NO2S
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Purity>98% (HPLC)
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SolubilityH2O:150 mg/mL (1374.26 mM)
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SMILESNCCS(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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DCPIB
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels.?DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC), has been reported to activate TREK1 and TREK2 in astrocytes and in vitro recently.?
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Guanidinoethyl sulfo...
Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
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GaTx2
Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
