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SGC-GAK-1

CAS No. 2226517-76-4

SGC-GAK-1( —— )

Catalog No. M19961 CAS No. 2226517-76-4

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	45	In Stock
5MG	41	In Stock
10MG	69	In Stock
25MG	141	In Stock
50MG	221	In Stock
100MG	328	In Stock
200MG	458	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SGC-GAK-1
Note

Research use only, not for human use.
Brief Description

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
Description

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
In Vitro

Cell Viability Assay Cell Line:Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145) Concentration:0.1, 1, and 10 μM Incubation Time:48 hours or 72 hours Result:Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 μM and 0.17±0.65 μM, respectively.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

GAK
Research Area

——
Indication

——

Chemical Information

CAS Number

2226517-76-4
Formula Weight

389.24
Molecular Formula

C18H17BrN2O3
Purity

>98% (HPLC)
Solubility

DMSO: 40 mg/mL;Ethanol: 15 mg/mL
SMILES

COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC
Chemical Name

6-Bromo-N-(345-trimethoxyphenyl)quinolin-4-amine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Asquith CRM et al. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem. 2019 Feb 26.

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