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Cabozantinib hydrochloride
CAS No. ——
Cabozantinib hydrochloride ( XL184 | BMS-907351 )
Catalog No. M19952 CAS No. ——
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
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| 5MG | 70 | Get Quote |
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| 10MG | 108 | Get Quote |
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| 25MG | 188 | Get Quote |
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| 50MG | 283 | Get Quote |
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| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCabozantinib hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
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DescriptionCabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
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In Vitro——
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In Vivo——
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SynonymsXL184 | BMS-907351
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PathwayAngiogenesis
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Targetc-Met/HGFR
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Recptorc-Kit| c-Met| VEGFR2/KDR| FLT4| Axl|RORγ|RORα
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Research AreaCancer
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IndicationAdrenocortical carcinoma; Bone metastases; Brain metastases; Breast Cancer; Cholangiocarcinoma; Endometrial Cancer; Ewing's sarcoma
Chemical Information
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CAS Number——
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Formula Weight537.96
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Molecular FormulaC28H25ClFN3O5
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Purity>98% (HPLC)
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SolubilityDMSO: 80 mg/mL
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SMILESCl.COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yakes FM et al. Cabozantinib (XL184) a novel MET and VEGFR2 inhibitor simultaneously suppresses metastasis angiogenesis and tumor growth. Mol Cancer Ther 2011 10(12) 2298-2308.
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