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C176
CAS No. 314054-00-7
C176( C 176 | C-176 | STING inhibitor 1 )
Catalog No. M19948 CAS No. 314054-00-7
C-176 is a highly potent and covalent mouse STING inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 88 | In Stock |
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| 50MG | 123 | In Stock |
|
| 100MG | 222 | In Stock |
|
| 200MG | 330 | In Stock |
|
| 500MG | 536 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameC176
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NoteResearch use only, not for human use.
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Brief DescriptionC-176 is a highly potent and covalent mouse STING inhibitor.
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DescriptionC-176 is a highly potent and covalent mouse STING inhibitor.(In Vitro):C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.(In Vivo):C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 / mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 / mice.
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In VitroC-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
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In VivoC-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice. Animal Model:WT type mice.Dosage:750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).Administration:Intraperitoneally, once.Result:Significantly reduced Serum levels of type I IFNs and IL-6.
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SynonymsC 176 | C-176 | STING inhibitor 1
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PathwayImmunology/Inflammation
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TargetSTING
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RecptorSTING
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Research Area——
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Indication——
Chemical Information
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CAS Number314054-00-7
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Formula Weight358.09
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Molecular FormulaC11H7IN2O4
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL
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SMILES[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1
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Chemical NameN-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Haag SM et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
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