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STING agonist-4
CAS No. 2138300-40-8
STING agonist-4( —— )
Catalog No. M26467 CAS No. 2138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameSTING agonist-4
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NoteResearch use only, not for human use.
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Brief DescriptionSTING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
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DescriptionSTING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).(In Vitro):STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.
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In VitroSTING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (Kd) of approximately 1.6 nM.STING agonist-4 (Compound 2) (0-100μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.Cell Viability Assay Cell Line:Human peripheral blood mononuclear cells (PBMCs) Concentration:0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM Incubation Time:2 hours Result:Causedphosphorylation of IRF3 and STING and induced secretion of IFN-β.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetSTING
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Recptoracetolactate synthase (ALS)
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Research Area——
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Indication——
Chemical Information
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CAS Number2138300-40-8
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Formula Weight678.758
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Molecular FormulaC34H38N12O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (14.73 mM)
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SMILESCCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhao W, Wang C, Xu L, Zhao C, Liang H, Qiu L. Biodegradation of nicosulfuron by a novel Alcaligenes faecalis strain ZWS11. J Environ Sci (China). 2015 Sep 1;35:151-162.
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