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AG 99

CAS No. 122520-85-8

AG 99( (E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46 )

Catalog No. M19940 CAS No. 122520-85-8

AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 42 In Stock
10MG 33 In Stock
25MG 59 In Stock
50MG 82 In Stock
100MG 114 In Stock
200MG 166 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AG 99
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
  • Description
    AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
  • In Vitro
    (E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases.
  • In Vivo
    ——
  • Synonyms
    (E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    122520-85-8
  • Formula Weight
    204.18
  • Molecular Formula
    C10H8N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL;Ethanol: 1 mg/mL;Water: Insoluble
  • SMILES
    NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gazit A et al. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem. 1996 Dec 6;39(25):4905-11.
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