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AZD8931 diFuMaric acid
CAS No. 1196531-39-1
AZD8931 diFuMaric acid( —— )
Catalog No. M22731 CAS No. 1196531-39-1
AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.AZD8931 monotherapy inhibited xenograft growth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 179 | In Stock |
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| 5MG | 121 | In Stock |
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| 10MG | 181 | In Stock |
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| 25MG | 297 | In Stock |
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| 50MG | 410 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | 736 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD8931 diFuMaric acid
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NoteResearch use only, not for human use.
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Brief DescriptionAZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.AZD8931 monotherapy inhibited xenograft growth.
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DescriptionAZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.AZD8931 monotherapy inhibited xenograft growth.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR|ErbB2|ErbB3
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Research Area——
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Indication——
Chemical Information
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CAS Number1196531-39-1
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Formula Weight706.1
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Molecular FormulaC31H33ClFN5O11
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhaomei Mu,Teresa Klinowska,Xiaoshen Dong,et al.AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models.J Exp Clin Cancer Res. 2014 May 30;33(1):47.
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