Ondansetron

CAS No. 99614-02-5

Ondansetron( GRC50775 | SN307 )

Catalog No. M19306 CAS No. 99614-02-5

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 52 In Stock
25MG 44 In Stock
100MG 63 In Stock
200MG 93 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ondansetron
  • Note
    Research use only, not for human use.
  • Brief Description
    Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
  • Description
    This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
  • In Vitro
    ——
  • In Vivo
    Animal Model:NSCLC Patients Treated With Chemotherapy Dosage:8 mg Administration:Intraperitoneal Injection (i.p.)Result:Showed TD50 and LD50 doses with 3.7±0.6 mg/kg and 4.6±0.5 mg/kg, respectively.Animal Model:Male Swiss Mice with Colitis Dosage:2 mg/kg Administration:Intraperitoneal Injection (i.p.)Result:Showed dramatic reduction in MPO activity and tumor necrosis factor-alpha, interleukin-6 and interleukin-1 beta.
  • Synonyms
    GRC50775 | SN307
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT3 receptor
  • Research Area
    Cancer|Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    99614-02-5
  • Formula Weight
    293.36
  • Molecular Formula
    C18H19N3O
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : < 0.1 mg/mL DMSO : < 1 mg/mL
  • SMILES
    CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
  • Chemical Name
    1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1- yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Haj-Mirzaian A, et al. Eur J Pharmacol. 2016 Mar 19. pii: S0014-2999(16)30157-1.
molnova catalog
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