Ondansetron( GRC50775 | SN307 )

Catalog No. M19306 CAS No. 99614-02-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ondansetron
Note

Research use only, not for human use.
Brief Description

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
Description

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
In Vitro

——
In Vivo

Animal Model:NSCLC Patients Treated With Chemotherapy Dosage:8 mg Administration:Intraperitoneal Injection (i.p.)Result:Showed TD50 and LD50 doses with 3.7±0.6 mg/kg and 4.6±0.5 mg/kg, respectively.Animal Model:Male Swiss Mice with Colitis Dosage:2 mg/kg Administration:Intraperitoneal Injection (i.p.)Result:Showed dramatic reduction in MPO activity and tumor necrosis factor-alpha, interleukin-6 and interleukin-1 beta.
Synonyms

GRC50775 | SN307
Pathway

Others
Target

Other Targets
Recptor

5-HT3 receptor
Research Area

Cancer|Neurological Disease
Indication

——

CAS Number

99614-02-5
Formula Weight

293.36
Molecular Formula

C18H19N3O
Purity

>98% (HPLC)
Solubility

H2O : < 0.1 mg/mL DMSO : < 1 mg/mL
SMILES

CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
Chemical Name

1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1- yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate

1. Haj-Mirzaian A, et al. Eur J Pharmacol. 2016 Mar 19. pii: S0014-2999(16)30157-1.

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