Ondansetron

Research use only, not for human use.

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

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Animal Model:NSCLC Patients Treated With Chemotherapy Dosage:8 mg Administration:Intraperitoneal Injection (i.p.)Result:Showed TD50 and LD50 doses with 3.7±0.6 mg/kg and 4.6±0.5 mg/kg, respectively.Animal Model:Male Swiss Mice with Colitis Dosage:2 mg/kg Administration:Intraperitoneal Injection (i.p.)Result:Showed dramatic reduction in MPO activity and tumor necrosis factor-alpha, interleukin-6 and interleukin-1 beta.

GRC50775 | SN307

Others

Other Targets

5-HT3 receptor

Cancer|Neurological Disease

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99614-02-5

293.36

C18H19N3O

>98% (HPLC)

H2O : < 0.1 mg/mL DMSO : < 1 mg/mL

CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C

1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1- yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate

(-20℃)

With Ice Pack

≥ 2 years