Erianin

Research use only, not for human use.

Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity, can cause extensive tumour necrosis, growth delay.

Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metabolism in a JNK/SAPK-dependent manner and inducing endothelial cytoskeletal disorganisation. Erianin shows potent inhibitory activity on the proliferation of HL-60 cells, the inhibition might be relative to the apoptosis induced by Erianin and the altered expression of bcl-2 and bax genes in HL-60 cells.

Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose? and time?dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase?3, but decreases levels of Bcl?2 and phosphorylated?ERK1/2.

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Others

Other Targets

Bcl-2

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95041-90-0

318.37

C18H22O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (314.11 mM)

COc1c(cc(cc1)CCc1cc(c(c(c1)OC)OC)OC)O

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(-20℃)

With Ice Pack

≥ 2 years