ML365

Research use only, not for human use.

ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).

ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.

ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM).ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG).ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM.

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ML365 | ML-365 | ML 365

Angiogenesis

CDK

TASK-1

Cardiovascular Disease

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947914-18-3

360.41

C22H20N2O3

>98% (HPLC)

DMSO : ≥ 100 mg/mL 277.46 mM H2O : < 0.1 mg/mL

COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

(-20℃)

With Ice Pack

≥ 2 years