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WHI-P180

CAS No. 211555-08-7

WHI-P180( Janex 3 )

Catalog No. M13366 CAS No. 211555-08-7

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	44	In Stock
5MG	40	In Stock
10MG	61	In Stock
25MG	129	In Stock
50MG	184	In Stock
100MG	291	In Stock
200MG	434	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

WHI-P180
Note

Research use only, not for human use.
Brief Description

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Description

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
In Vitro

——
In Vivo

WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
Synonyms

Janex 3
Pathway

Angiogenesis
Target

CDK
Recptor

CDK2| EGFR
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

211555-08-7
Formula Weight

297.31
Molecular Formula

C16H15N3O3
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

OC1=CC=CC(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1
Chemical Name

3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.An R, et al. Pharm Res. 2009 Feb;26(2):449-58.

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