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HC-067047
CAS No. 883031-03-6
HC-067047( HC-067047 | HC 067047 | HC067047 )
Catalog No. M19226 CAS No. 883031-03-6
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 5MG | 59 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 491 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHC-067047
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NoteResearch use only, not for human use.
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Brief DescriptionHC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
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DescriptionHC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder
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In VitroHC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.?HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis. RT-PCR Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The mRNA expression was significantly decreased.Western Blot Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The expression of TRPV4 protein was significantly decreased.Cell Proliferation Assay Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hours Result:Inhibited cell proliferation.Apoptosis Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hoursResult:Promoted cell apoptosis.
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In VivoAnimal Model:Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT miceDosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg Administration:Intraperitoneal injection; for 30 minutes Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.
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SynonymsHC-067047 | HC 067047 | HC067047
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PathwayOthers
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TargetOther Targets
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RecptorhTRPV4/mTRPV4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number883031-03-6
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Formula Weight471.51
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Molecular FormulaC26H28F3N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 106.04 mM
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SMILESFC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C
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Chemical Name2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
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