Glaucocalyxin A
CAS No. 79498-31-0
Glaucocalyxin A( —— )
Catalog No. M19111 CAS No. 79498-31-0
Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 227 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGlaucocalyxin A
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NoteResearch use only, not for human use.
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Brief DescriptionGlaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery.
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DescriptionGlaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.
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In VitroGlaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorCaspase-3|Akt
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Research Area——
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Indication——
Chemical Information
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CAS Number79498-31-0
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Formula Weight332.44
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Molecular FormulaC20H28O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (150.41 mM)
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SMILESCC1(C2CC(C34C(C2(CCC1=O)C)CCC(C3O)C(=C)C4=O)O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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