Cart
sales@molnova.com
AG18
CAS No. 118409-57-7
AG18( RG-50810 | RG-50858 | TX 825 | Tyrphostin 23 | Tyrphostin AG-18 )
Catalog No. M10624 CAS No. 118409-57-7
AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 34 | In Stock |
|
| 10MG | 51 | In Stock |
|
| 25MG | 118 | In Stock |
|
| 50MG | 219 | In Stock |
|
| 100MG | 330 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAG18
-
NoteResearch use only, not for human use.
-
Brief DescriptionAG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
-
DescriptionAG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
-
In Vitro10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure.
-
In Vivo——
-
SynonymsRG-50810 | RG-50858 | TX 825 | Tyrphostin 23 | Tyrphostin AG-18
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number118409-57-7
-
Formula Weight186.17
-
Molecular FormulaC10H6N2O2
-
Purity>98% (HPLC)
-
SolubilityEthanol: 37 mg/mL (198.74 mM); DMSO: 37 mg/mL (198.74 mM)
-
SMILESN#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
-
Chemical Name2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.
molnova catalog
related products
-
Dihydroberberine
Dihydroberberine has anti-atherosclerotic anti-inflammatory hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interaction with hERG.
-
O-Desmethyl gefitini...
O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib.
-
LY 456236 hydrochlor...
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.
