TOMATIDINE HYDROCHLORIDE

Research use only, not for human use.

A steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.

Tomatidine hydrochloride is a potent inhibitor of Staphylococcus aureus small-colony variants, and also indirectly inhibits iNOS and COX-2 pathways.

Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.

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Tomatidine hydrochloride | Tomatidine HCl

Neuroscience

GluR

Others

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6192-62-7

452.11

C27H46ClNO2

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (11.06 mMult)

Cl.C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@]11CC[C@H](C)CN1

(3beta,5alpha,22beta,25S)-Spirosolan-3-ol Hydrochloride

(-20℃)

With Ice Pack

≥ 2 years