4,5-Dicaffeoylquinic acid

Research use only, not for human use.

Isochlorogenic acid C(4, 5) has antiviral activity, including anti-HIV-1 integrase activity.

Isochlorogenic acid C(4, 5) has antiviral activity, including anti-HIV-1 integrase activity. Isochlorogenic acid C(4, 5) shows anti-hepatotoxic activity.

4,5-Dicaffeoylquinic acid (0.1~100 μM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2.4,5-Dicaffeoylquinic acid (1~100 μg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 μg/mL.4,5-Dicaffeoylquinic acid (1~100 μg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 μg/mL on expressions of HBsAg and HBeAg, respectively. Cell Proliferation Assay Cell Line:DU-145 cells Concentration:0.1~100 μM Incubation Time:72 h Result:Exhibits dose-dependent inhibitory activity against DU-145 prostate cancer cells with an IC50 of 5 μM.Cell Cycle Analysis Cell Line:DU-145 cells Concentration:5 μMIncubation Time:72 h Result:Decreased in numbers in G0/G1 phase and increased in S phase.Apoptosis Analysis Cell Line:HL-7702 hepatocytes (exposure to 60 mM D-GalN for 6h) Concentration:1~100 μg/m L Incubation Time:48 h Result:Significantly reduced the caspase-3 and transforming growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes at 10~100 μg/mL.Cell Viability Assay Cell Line:HL-7702 hepatocytes (exposure to 80 mM D-GalN for 6h) Concentration:1~100 μg/mL Incubation Time:48 h Result:Improved significantly cell viability at concentrations of 10 to 100 μg/mL, and produced a maximum protection rate of 47.28% at 100 μg/mL.

4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice.

Isochlorogenic acid C

Others

Other Targets

Others

Infection

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57378-72-0

516.45

C25H24O12

>98% (HPLC)

DMSO : 50 mg/mL 96.81 mM

C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)OC(=O)C=CC3=CC(=C(C=C3)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years