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Sciadopitysin
CAS No. 521-34-6
Sciadopitysin( Sciadopitysin | NSC 45108 | NSC-45108 | NSC45108 )
Catalog No. M18713 CAS No. 521-34-6
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 125 | In Stock |
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| 5MG | 91 | In Stock |
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| 10MG | 157 | In Stock |
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| 25MG | 303 | In Stock |
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| 50MG | 445 | In Stock |
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| 100MG | 640 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1321 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSciadopitysin
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NoteResearch use only, not for human use.
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Brief DescriptionSciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.
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DescriptionSciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
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In VitroSciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1.
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In VivoSciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old).
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SynonymsSciadopitysin | NSC 45108 | NSC-45108 | NSC45108
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorTNF-α
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number521-34-6
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Formula Weight580.54
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Molecular FormulaC33H24O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (34.45 mM)
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SMILESOc1cc(OC)cc2OC(=CC(=O)c12)c6cc(c5c(O)cc(O)c3c5OC(=CC3=O)c4ccc(OC)cc4)c(OC)cc6
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Chemical Name5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Choi EM, et al.Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.Free Radic Res. 2014 Jul;48(7):729-39.
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