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Bilobetin
CAS No. 521-32-4
Bilobetin( —— )
Catalog No. M18712 CAS No. 521-32-4
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 186 | In Stock |
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| 2MG | 61 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 425 | In Stock |
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| 50MG | 601 | In Stock |
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| 100MG | 826 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBilobetin
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NoteResearch use only, not for human use.
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Brief DescriptionBilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
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DescriptionBilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
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In VitroCell Viability Assay Cell Line:Huh7 and HepG2 cells Concentration:0, 2.5, 5, 10, 20, and 40 μM Incubation Time:24/48/72 h Result:Inhibited cell proliferation in a dose dependent manner, with IC50s of 18.28 μM at 48 h in Huh7 cells, and 19 μM at 72 h in HepG2 cells.Apoptosis Analysis Cell Line:Huh7 and HepG2 cells Concentration:0, 2.5, 5, 10, 20 μM Incubation Time:24/48 h Result:Showed the total apoptotic cell rate of 2.2, 2.2, 1.9, and 10.6% for 24 h (Huh7 cells) at 0, 5, 10, and 20 μM, and 1.7, 1.5, 7.5, and 22.5% for 48 h (Huh7 cells) at 0, 5, 10, and 20 μM.Showed the total apoptotic cell rate of 1.1, 1.2, 1.6, and 3.0% for 24 h (Huh7 cells) at 0, 5, 10, and 20 μM, and 1.5, 1.1, 3.2, and 14.2% for 48 h (Huh7 cells) at 0, 5, 10, and 20 μM, respectively.
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In VivoAnimal Model:rats fed a high-fat dietDosage:12 mg/kg/dayAdministration:i.p., 4 or 14 days after mice were fed a HFD for 8 weeks.Result:Increased glucose infusion rate (GIR, P < 0.05) and reduced EGP (P < 0.05) in basal and clamp states.Reduced total TG (P < 0.01) and VLDL-TG (P < 0.01).Enhances hepatic Intralipid-TG uptake.Reduced the total amount of lipid level in the liver and muscle.Promoted the phosphorylation of PPARα and the translocation of PPARα from the cytoplasm to the nucleus in rats liver.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPPARα
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number521-32-4
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Formula Weight552.49
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Molecular FormulaC31H20O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (452.51 mM)
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SMILESOc1cc(O)cc2OC(=CC(=O)c12)c6cc(c5c(O)cc(O)c3c5OC(=CC3=O)c4ccc(O)cc4)c(OC)cc6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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[Lys3]–Bombesin
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