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Rhapontigenin

CAS No. 500-65-2

Rhapontigenin( —— )

Catalog No. M18663 CAS No. 500-65-2

Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rhapontigenin
  • Note
    Research use only, not for human use.
  • Brief Description
    Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.
  • Description
    Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:ICR mice Dosage:25mg/kg Administration:25mg/kg; intraperitoneal injection Result:Showed anti-thrombosis activity with 60% protection.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    CYP1A1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    500-65-2
  • Formula Weight
    258.3
  • Molecular Formula
    C15H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (483.99 mM)
  • SMILES
    COc1c(cc(cc1)/C=C/c1cc(cc(c1)O)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jo SP1, Kim JK2, Lim YH1.Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet.Planta Med. 2014 Aug;80(13):1067-71.
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