Ipratropium Bromide( Ipratropium Bromide )

Catalog No. M13553 CAS No. 22254-24-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ipratropium Bromide
Note

Research use only, not for human use.
Brief Description

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
Description

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
In Vitro

Cell Viability Assay Cell Line:Adult Rat Cardiac Myocyte Concentration:0.001 nM-0.1 mM Incubation Time:2 h in dark; prior to 4 h hypoxia Result:Resulted cell viability in a dose-dependent manner, with the inhibition rate of 52.7% at 0.1 mM dose.
In Vivo

Animal Model:Guinea-pigs of the Dunkin Hartley strain.Dosage:0.1-1 μg/kg Administration:Intravenous injection; single dose Result:Resulted little blocking effect on post-junctional muscarinic receptors at 0.3 μg/kg, and inhibited ACh-induced bronchoconstriction at 0.5 μg/kg.Animal Model:Male Sprague-Dawley rats (300-350 g) Dosage:0.04 mg/20 mL and 0.20 mg/20 mL Administration:Inhalation; atomization rate of 30 mL/30 min; 30 min Result:Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
Synonyms

Ipratropium Bromide
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

M3 mAChR
Research Area

Neurological Disease
Indication

——

CAS Number

22254-24-6
Formula Weight

412.37
Molecular Formula

C20H30BrNO3
Purity

>98% (HPLC)
Solubility

DMSO:83 mg/mL (201.27 mM); Ethanol:83 mg/mL (201.27 mM); Water:83 mg/mL (201.27 mM)
SMILES

CC([N+]1(C)C2CC(OC(C(C3=CC=CC=C3)CO)=O)CC1CC2)C.[Br-]
Chemical Name

(endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide

1. Zhang W, et al. Eur J Pharmacol,?010, 647(1-3), 178-187.

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