Methyl 4-hydroxycinnamate

Research use only, not for human use.

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.

Western Blot Analysis Cell Line:Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 1 h)-stimulated A549 cells Concentration:0-100 μM Incubation Time:1 h Result:Inhibited PMA-stimulated phosphorylation of IκBα and p65,as well as c-Jun/c-Fos phosphorylation and c-Jun/c-Fos nuclear translocation.

Animal Model:Ovalbumins (HY-W250978)-induced mice with allergic asthma Dosage:5 mg/kg Administration:p.o.Result:Inhibited the secretion of Th2 cytokines, MCP-1, and IgE.Inhibited eosinophil/macrophage influx.Inhibited immune cell influx and mucus secretion.

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GPCR/G Protein

Prostaglandin Receptor

Others

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3943-97-3

178.18

C10H10O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (561.23 mM)

COC(=O)/C=C/c1ccc(cc1)O

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(-20℃)

With Ice Pack

≥ 2 years