Methyl 4-hydroxycinnamate( —— )

Catalog No. M18519 CAS No. 3943-97-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Methyl 4-hydroxycinnamate
Note

Research use only, not for human use.
Brief Description

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.
Description

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.
In Vitro

Western Blot Analysis Cell Line:Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 1 h)-stimulated A549 cells Concentration:0-100 μM Incubation Time:1 h Result:Inhibited PMA-stimulated phosphorylation of IκBα and p65,as well as c-Jun/c-Fos phosphorylation and c-Jun/c-Fos nuclear translocation.
In Vivo

Animal Model:Ovalbumins (HY-W250978)-induced mice with allergic asthma Dosage:5 mg/kg Administration:p.o.Result:Inhibited the secretion of Th2 cytokines, MCP-1, and IgE.Inhibited eosinophil/macrophage influx.Inhibited immune cell influx and mucus secretion.
Synonyms

——
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

Others
Research Area

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Indication

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1. Tan EM, et al. J Phys Chem B. 2013 May 2;117(17):4798-805.

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