Methyl 4-hydroxycinnamate

CAS No. 3943-97-3

Methyl 4-hydroxycinnamate( —— )

Catalog No. M18519 CAS No. 3943-97-3

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
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200MG Get Quote In Stock
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1G 27 In Stock

Biological Information

  • Product Name
    Methyl 4-hydroxycinnamate
  • Note
    Research use only, not for human use.
  • Brief Description
    Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.
  • Description
    Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.
  • In Vitro
    Western Blot Analysis Cell Line:Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 1 h)-stimulated A549 cells Concentration:0-100 μM Incubation Time:1 h Result:Inhibited PMA-stimulated phosphorylation of IκBα and p65,as well as c-Jun/c-Fos phosphorylation and c-Jun/c-Fos nuclear translocation.
  • In Vivo
    Animal Model:Ovalbumins (HY-W250978)-induced mice with allergic asthma Dosage:5 mg/kg Administration:p.o.Result:Inhibited the secretion of Th2 cytokines, MCP-1, and IgE.Inhibited eosinophil/macrophage influx.Inhibited immune cell influx and mucus secretion.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3943-97-3
  • Formula Weight
    178.18
  • Molecular Formula
    C10H10O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (561.23 mM)
  • SMILES
    COC(=O)/C=C/c1ccc(cc1)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tan EM, et al. J Phys Chem B. 2013 May 2;117(17):4798-805.
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