Furanodienone

Research use only, not for human use.

Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling.

Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependent on the expression of HER2 but not EGFR .

Furanodienone (0-573.8?μM; 24? hours) exhibits IC50 values : 56.4?μM (RKO), 73.7?μM (sw480), 251.1?μM (HT-29), 412.5?μM (sw620) and 573.8?μM (LoVo) at 24 hours, while that in 48?h are 51.8?μM (RKO), 44.18?μM (sw480), 168.9?μM (HT-29), 314.2?μM (sw620) and 502.1?μM (LoVo), respectively.Furanodienone (0-150 μM; 24? hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells.Furanodienone (0-150?μM; 24 ?hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150?μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150?μM are observed in HT-29 cells compared with 2.89±0.26%. Western Blot Analysis Cell Line:RKO and HT-29 cells Concentration:0 μM; 50 μM; 100 μM; 150 μM Incubation Time:24 hours Result:Increased caspase-9 and -3.Apoptosis Analysis Cell Line:RKO and HT-29 cells Concentration:0 μM; 75 μM; 150 μM Incubation Time:24 hours Result:Induced apoptosis of colorectal cells (RKO and HT-29).

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Others

Other Targets

HER2

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24268-41-5

230.3

C15H18O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (434.22 mM)

CC1=CC(=O)C2=C(CC(=CCC1)C)OC=C2C

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(-20℃)

With Ice Pack

≥ 2 years