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VT107

CAS No. 2417718-63-7

VT107( —— )

Catalog No. M34767 CAS No. 2417718-63-7

VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 342 In Stock
5MG 314 In Stock
10MG 477 In Stock
25MG 769 In Stock
50MG 1023 In Stock
100MG 1376 In Stock
200MG 1841 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VT107
  • Note
    Research use only, not for human use.
  • Brief Description
    VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.
  • Description
    VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.
  • In Vitro
    Western Blot Analysis Cell Line:HEK293T cells Concentration:3 μmol/L Incubation Time:20 hours Result:Inhibited palmitoylation of both endogenous TEAD1 and TEAD3 proteins and was the most potent at blocking the palmitoylation of endogenous TEAD4 protein.
  • In Vivo
    Animal Model:MouseDosage:10 mg/kg (Pharmacokinetic Analysis) Administration:P.o.Result:Enantiomer analogous to VT104.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    YAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2417718-63-7
  • Formula Weight
    435.44
  • Molecular Formula
    C25H20F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (229.65 mM; Ultrasonic )
  • SMILES
    C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1cccc(N)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021; 20(6):986-998.?
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